Our ultimate goal is to develop the nasal applicative formulation which can efficiently deliver the drug to the brain/central nervous system (CNS) which drug entry is limited due to the blood-brain barrier (BBB). To achieve the goal, we must overcome the two important challenges, first is understanding the direct drug transport mechanism from the nose to the brain, called “Nose-to-Brain (N2B) route”, and second is developing an innovative brain-targeting nanotechnology. We aim to develop the ideal nasal applicative formulation for treating brain/CNS diseases by maximum effect with minimal side effects.